Last edited by Nigal
Tuesday, May 19, 2020 | History

2 edition of Replication-Competent Viruses for Cancer Therapy (Monographs in Virology) found in the catalog.

Replication-Competent Viruses for Cancer Therapy (Monographs in Virology)

  • 170 Want to read
  • 19 Currently reading

Published by S Karger Pub .
Written in English

    Subjects:
  • Infectious Diseases,
  • Microbiology,
  • Oncology,
  • Cancer Chemotherapy,
  • Medical Virology,
  • Medical

  • Edition Notes

    ContributionsPablo Hernaiz Driever (Editor), S. D. Rabkin (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages188
    ID Numbers
    Open LibraryOL12931304M
    ISBN 103805572484
    ISBN 109783805572484

      However, each virus activates innate immune system by using different combination of recognition receptors/pathways which leads to qualitatively different adaptive immune responses. This review summarizes immunological findings in cancer patients following treatment with replication-competent by: An oncolytic virus is a virus that preferentially infects and kills cancer the infected cancer cells are destroyed by oncolysis, they release new infectious virus particles or virions to help destroy the remaining tumour. Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour immune system responses.

    Oncolytic Virotherapy is an exciting, increasingly recognized discipline in cancer research. Although the connection between viruses and cancer regression was recognized in the early 20th century, it wasn’t until the recent development of advanced genetic engineering techniques that true progress has been made using virotherapy to attack and destroy cancer cells.   Herpes simplex virus (HSV) was originally used as an oncolytic virus therapy between and when two different research groups used G 1, 2 and HSV 3, 4 to treat recurrent malignant Cited by:

    Search the world's most comprehensive index of full-text books. My library. A retrovirus is any virus belonging to the viral family The genetic material in retroviruses is in the form of RNA molecules, while the genetic material of their hosts is in the form of a retrovirus infects a host cell, it will introduce its RNA together with some enzymes into the cell. This RNA molecule from the retrovirus must produce a DNA copy from its RNA.


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Replication-Competent Viruses for Cancer Therapy (Monographs in Virology) Download PDF EPUB FB2

Replication-Competent Viruses for Cancer Therapy (Monographs in Virology, Vol. 22) [Hernaíz Driever, P., Rabkin, S.D., Preiser, W.] on *FREE* shipping on.

Replication-competent herpes simplex virus vectors for cancer therapy; dl (ONYX) as an antitumour agent; attenuated replication-competent adenoviruses (ARCA) for prostate cancer - CV to CV; reovirus as a potential anticancer therapeutic; autonomous parvoviruses; vaccinia virus; replication-competent, oncolytic Newcastle disease virus for cancer therapy.

Introduction --Replication-Competent Herpes Simplex Virus Vectors for Cancer Therapy --dl (ONYX) as an Antitumor Agent --Attenuated Replication-CompetentAdenoviruses (ARCA©) for ProstateCancer: CV to CV --Reovirus as a Potential Anticancer Therapeutic --Autonomous Parvoviruses --Vaccinia Virus --Replication-Competent, Oncolytic Newcastle Disease Virus.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Applications of viruses for cancer therapy". With outstanding and original reviews, this volume covers topics such as Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes, esign of improved Format: Hardcover.

At Cell Genesys Dr. Burke designed and implemented early phase clinical trials of replication-competent adenoviruses for bladder and prostate cancer. In addition to his work on oncolytic viruses, Dr. Burke has also led clinical efforts for the clinical application of AAV, lentivirus, and cancer by: This thematic volume looks at "Applications of viruses for cancer therapy".

With outstanding and original reviews, this volume covers topics such as Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes, esign of improved oncolytic adenoviruses, and Adenovirus-based immunotherapies for cancer.

Abstract. Advances in our understanding of the molecular basis of cancer and the availability of technology to genetically engineer viruses have led to the development of replication-competent viruses to treat cancer. In theory, replication-selective viruses offer several appealing properties as biological agents for cancer therapy: they kill tumor Cited by:   Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer.

Describes the use of viruses as oncolytic agents, killing cells directly. Editors are experts in the field, with experience of both laboratory and clinical research. [CANCER RESEA –, Ma ] Validation and Analysis of a Mathematical Model of a Replication-competent Oncolytic Virus for Cancer Treatment: Implications for Virus Design and Delivery Lawrence M.

Wein, Joseph T. Wu, and David H. Kirn 1Cited by:   Oncolytic virus therapy has recently been recognized as a promising new therapeutic approach for cancer treatment.

An oncolytic virus is defined as a genetically engineered or naturally occurring virus that can selectively replicate in and kill cancer cells without harming the normal tissues.

In contrast to gene therapy where a virus is used as a mere carrier for transgene delivery, oncolytic virus therapy uses the virus Cited by: Viral vectors have natural host cell populations that they infect most efficiently. Retroviruses have limited natural host cell ranges, and although adenovirus and adeno-associated virus are able to infect a relatively broader range of cells efficiently, some cell types are refractory to infection by these viruses as well.

Attachment to and entry into a susceptible cell is mediated by the. Replication-competent retrovirus vectors for cancer gene therapy. Oncolytic virotherapy represents an emerging field with tremendous promise for harnessing the replicative capabilities of viruses against rapidly proliferating cancer cells.

Volker Schirrmacher. Oncolytic viruses (OVs) replicate selectively in tumor cells and exert anti-tumor cytotoxic activity. Among them, Newcastle Disease Virus (NDV), a bird RNA virus of the paramyxovirus family, appears outstanding. Its anti-tumor effect is based on: (i) oncolytic activity and (ii) immunostimulation.

Replication-competent viral agents may provide a feasible complement to traditional cancer therapies. Several viral-based, oncolytic strategies are currently being evaluated as effective treatments for multiple malignancies.Cited by:   Replication-competent (oncolytic) viruses (OV) as cancer immunotherapeutics have gained an increasing level of attention over the last few years while the clinical evidence of virus-mediated antitumor immune responses is still by:   Purchase Viruses, Cell Transformation, and Cancer, Volume 5 - 1st Edition.

Print Book & E-Book. ISBNBook Edition: 1. Use of a replication-competent retroviral vector encoding a therapeutic gene for treatment of experimental brain tumors has been recently reported.

14, 15 However, as epitomized by these studies Cited by: Abstract Oncolytic virus therapy is a promising new strategy for treating cancer that involves replication-competent virus vectors that can replicate in situ in tumor cells, exhibit oncolytic activity by direct cytocidal effects, and then spread throughout the by: 1.

Received: 2 March, Accepted: 29 April, Invited Review Advances in Gene, Molecular and Cell Therapy © Global Science Books Importance of Viruses and Cells in Cancer Gene Therapy Vaibhav Saini1,2 • Justin C. Roth1 •Larisa Pereboeva1,3 Maaike Everts1,3* 1 Division of Human Gene Therapy, Departments of Medicine, Obstetrics and Gynecology.

As cancer gene therapy employing replication-defective vectors has met with limited clinical success, there is renewed interest in using replication-competent viruses for oncolytic virotherapy. In preclinical and clinical studies, various attenuated vaccine strains and engineered virus vectors are currently being tested for their ability to Cited by:.

Abstract. Purpose: Seneca Valley Virus (SVV) is a novel naturally occurring replication-competent picornavirus with potent and selective tropism for neuroendocrine cancer cell types, including small cell lung cancer.

We conducted a first-in-human, first-in-class phase I clinical trial of this agent in patients with cancers with neuroendocrine features, including small cell lung by: Immunotherapy is a type of cancer treatment that helps your immune system fight cancer. The immune system helps your body fight infections and other diseases.

It is made up of white blood cells and organs and tissues of the lymph system. Immunotherapy is a type of biological ical therapy is a type of treatment that uses substances made from living organisms to treat cancer.Latest cancer articles, treatment info, research news and more for oncologists and medical professionals.

Read featured content on cancer research, treatment regimens and .